From Mechanism to Medicine
Buy major cialis inhibits PDE5, protecting cGMP in smooth muscle. The result is more sustained relaxation of vascular and urinary tract smooth muscle, which translates into clinical effects across several organ systems.
Validated Uses
ED: enhances erectile response to sexual stimulation with a flexible window of action.
BPH-associated LUTS: reduces urinary urgency and frequency by easing outflow resistance.
PAH: supports pulmonary vascular relaxation and exercise capacity when used appropriately.
Exploratory Uses
Raynaud's phenomenon, certain muscle perfusion disorders, ureteral stone passage, and trials probing vascular contributions to cognition are under investigation.
Key Takeaways of tadalafil
- Common effects: headache, flushing, nasal congestion; usually mild.
- Long half-life (17.5 hours) enables once-daily or on-demand dosing.
- PDE5 inhibitor that raises cGMP and relaxes smooth muscle.
- Food has minimal impact; alcohol and grapefruit may interact.
- Approved for ED, BPH-associated LUTS, and PAH (as Adcirca).
- Not a cure; works in presence of sexual stimulation for ED.
- Avoid combining with nitrates or riociguat due to dangerous blood pressure drops.
- Dose adjustments may be needed with strong CYP3A4 inhibitors/inducers.